top of page

NUYU is customised and comprehensive medical weight loss management that supports

you to do you.

No judgement, just support, empowering people to be their best selves.

What is Tirzepatide?

  • FDA-approved medication for type 2 diabetes (brand name: Mounjaro)

  • Also approved for weight management (brand name: Zepbound)

  • Belongs to a class of medications called dual GIP/GLP-1 receptor agonists

  • Weekly injection using a pre-filled pen

Indications: Who Can Consider Tirzepatide?

  • Adults with obesity (BMI ≥30 kg/m²)

  • Adults with overweight (BMI ≥27 kg/m²) with at least one weight-related condition:

    • High blood pressure

    • Type 2 diabetes

    • High cholesterol

    • Sleep apnea

  • Should be used alongside diet and exercise

Aerial View of Surfers

How Tirzepatide Works

  • Acts as a dual agonist targeting two incretin hormones:

    1. GLP-1 (glucagon-like peptide-1)

    2. GIP (glucose-dependent insulinotropic polypeptide)

  • Both hormones are naturally released by intestinal cells after eating

  • Tirzepatide binds to both hormone receptors more strongly and lasts longer than natural hormones

Detailed Mechanism of Action: GLP-1 Effects

Tirzepatide activates GLP-1 receptors to:

  • Slow stomach emptying (gastroparesis), keeping food in stomach longer

  • Increase feeling of fullness by acting on appetite centers in the brain

  • Reduce food intake by decreasing hunger signals

  • Improve insulin secretion in response to glucose (glucose-dependent)

  • Decrease glucagon secretion from the pancreas, reducing liver glucose production

  • Slow absorption of nutrients into the bloodstream

Detailed Mechanism of Action: GIP Effects

Tirzepatide activates GIP receptors to:

  • Enhance insulin response when blood sugar levels are elevated

  • Improve fat metabolism in adipose (fat) tissue

  • Reduce fat storage by altering fat cell function

  • Complement and enhance the effects of GLP-1 activation

  • Potentially reduce inflammation in fat tissue

when-are-Newcastle-baths-open.jpg

​

AdobeStock_1265184386.jpeg

The Dual-Action Advantage

  • Synergistic effect: Combined action on both receptors creates greater impact than either alone

  • Enhanced weight loss: Affects multiple pathways in appetite regulation and metabolism

  • Better glycemic control: More powerful effect on insulin and glucagon than single-target medications

  • Central nervous system effects: May affect reward pathways related to food consumption

  • Energy expenditure: Some evidence suggests potential increase in energy use

Beauty Spa

How This Translates to Weight Loss

Reduced calorie intake through multiple mechanisms:

  • Feeling full more quickly when eating

  • Feeling satisfied longer between meals

  • Reduced hunger signals throughout the day

  • Potentially decreased interest in food (especially high-calorie foods)

Improved metabolic function:

  • Better insulin sensitivity

  • More efficient fat metabolism

  • Reduced fat storage

Benefits of Tirzepatide

  • Significant weight loss

  • Average 20-22% body weight reduction in clinical trials

  • Improved blood sugar control for patients with type 2 diabetes

Additional health benefits:

  • Improved cholesterol levels

  • Reduced blood pressure

  • Better quality of life

  • Reduced cardiovascular risk factors

Flowers

Key Clinical Evidence: The SURMOUNT Trials

​

SURMOUNT-1 Study Results:

​

72-week trial with 2,539 adults without diabetes

Weight loss results:​

​

​​

  • 5 mg dose: Average of 16.0% body weight loss

  • 10 mg dose: Average of 21.4% body weight loss

  • 15 mg dose: Average of 22.5% body weight loss

Any Qs So Far?

Sad on Couch

Digestive system effects

  • Nausea (most common, affects 24-30% of patients)

  • Diarrhea (affects 18-23% of patients)

  • Vomiting (affects 12-21% of patients)

  • Constipation (affects 17-19% of patients)

  • Abdominal pain (affects 10-12% of patients)

  • Dyspepsia/indigestion (affects 8-9% of patients)

Other System Effects

  • Decreased appetite (affects 10-12% of patients)

  • Fatigue (affects 7-10% of patients)

  • Injection site reactions (redness, itching, swelling)

  • Headache (affects 5-7% of patients)

  • Dizziness (affects 4-8% of patients)

  • Hair loss (reported in some patients)

Side Effects

Managing Side Effects​

  • Start with lower doses and increase gradually (dose titration)

  • Stay well hydrated throughout the day

  • Eat smaller, more frequent meals rather than large meals

  • Avoid high-fat or very spicy foods which may worsen digestive symptoms

  • Contact your healthcare provider if side effects are severe or persistent

  • Don't stop taking medication without consulting your provider

Pancreatitis

 

  • Inflammation of the pancreas (incidence rate 0.1-0.2%)

  • Symptoms: severe abdominal pain, sometimes radiating to back, nausea, vomiting

  • Requires immediate medical attention

Om Symbol on the Beach

Gall Bladder Problems

  • Increased risk of gallstones and cholecystitis

  • More common with rapid weight loss

  • Symptoms: pain in upper right abdomen, nausea, vomiting, fever

Stone Mortar and Pestle
Rock Balancing

Hypoglycemia
(low blood sugar)

  • More common in patients taking insulin or sulfonylureas

  • Symptoms: shakiness, sweating, confusion, irritability, dizziness

  • Risk can be reduced by appropriate dose adjustments of other medications

Spa and Wellness

Acute Kidney Injury

  • Risk increases with dehydration from severe vomiting or diarrhea

  • Patients with pre-existing kidney disease need closer monitoring

Diabetic Retinopathy Complications

Diabetic retinopathy complications:

  • Potential worsening in patients with pre-existing diabetic retinopathy

  • Regular eye exams recommended

Friends at the Beach

Thyroid C Cell Tumours

​

  • Rare but serious risk based on animal studies
  • Contraindicated in patients with personal/family history of medullary thyroid carcinoma (MTC)

  • Also contraindicated with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Relax

So What Now?

Woman

One Question

'Is this right for me?'

There are four things to consider

01

You have obesity or overweight with weight-related conditions

02

Diet and exercise alone have not been effective

03

You can commit to weekly injections and lifestyle changes

04

You have no contraindications for this medication

bottom of page